Post Doctoral Fellow - Department of Microbiology & Immunology - Lab of Dr. Igyarto

Job Details The Igyártó laboratory at Thomas Jefferson University is supported by NIH and the LEO Foundation. The lab is seeking well-trained, highly motivated postdoctoral fellows with a Ph.D. in immunology or a related field who can drive projects with minimal oversight. Candidates with experience in mouse models, mouse and human dendritic cells (DCs), flow cytometry, histology, imaging, and molecular/omics approaches (RNA-seq, ATAC-seq, ChIP-seq, microarray, CRISPR-Cas9, etc.) are especially encouraged to apply.

Job Description

• Projects
• Regulation of humoral immune responses by distinct DC subsets – toward DC-tailored vaccines Our work shows that specific DC subsets, contrary to the textbook model, can elicit protective antibody responses even in the absence of inflammation and canonical cytokines. Defining how DCs support such “steady-state” humoral immunity will inform the design of adjuvant-free vaccines with reduced side effects and may open new avenues to prevent or treat autoimmunediseases such as lupus and pemphigus.
• Intracellular monitoring and surveillance by DCs We recently discovered that DCs are not mere scavengers of extracellular material; they can actively siphon specific RNAs from neighboring cells through a previously unrecognizedmechanism. This form of intracellular monitoring likely shapes many facets of immunity, including tolerance induction, responses to intracellular pathogens, tumor immunology,metabolism, and transplantation. Fellows will have the opportunity to connect this pathway to their disease or mechanistic area of interest and help define a new chapter in immunology.
• Trained immunity induced by mRNA-LNP vaccination and its transgenerational inheritance Emerging data from the lab indicate that mRNA-lipid nanoparticle (LNP) formulations can imprint long-lasting functional changes in innate immune cells consistent with trained immunity. We aim to dissect the molecular and epigenetic mechanisms underlying this reprogramming, determine its impact on subsequent infections and vaccinations, and test how these traits are transmitted across generations. This project integrates in vivo models, innate immune profiling, and multi-omics toredefine how vaccines shape immunity over the life course and beyond. Application instructions Interested candidates are encouraged to contact Dr. Igyártó directly. Please include:
• A cover letter describing your past research accomplishments, future research interests, and career goals
• CV
• Contact information for your Ph.D. mentor (and, if applicable, current supervisor) Work Shift Workday Day (United States of America) Worker Sub Type Regular Employee Entity Thomas Jefferson University Primary Location Address 951 Locust Street, Philadelphia, Pennsylvania, United States of America Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University, home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200+ undergraduate and graduate programs to more than 8,300 students. Jefferson Health, nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas, serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years. Jefferson is committed to providing equal educational and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status. Benefits Jefferson offers a comprehensive package of benefits for full-time and part-time colleagues, including medical (including prescription), supplemental insurance, dental, vision, life and AD&D insurance, short- and long-term disability, flexible spending accounts, retirement plans, tuition assistance, as well as voluntary benefits, which provide colleagues with access to group rates on insurance and discounts. Colleagues have access to tuition discounts at Thomas Jefferson University after one year of full time service or two years of part time service. All colleagues, including those who work less than part-time (including per diem colleagues, adjunct faculty, and Jeff Temps), have access to medical (including prescription) insurance. For more benefits information, please click here In keeping with Jefferson's Mission, We Improve Lives, it is our goal to recruit, retain, develop and reward highly-qualified employees. If you are enthusiastic, caring and dedicated to service excellence, we invite you to consider joining Jefferson. Jefferson encourages its employees to expand their knowledge and develop their careers through growth opportunities and continuing education. With a long standing history, Jefferson has been advancing the medical field from the heart of Center City Philadelphia for nearly 200 years. Our Mission, We Improve Lives, expands to every corner of the organization. From our weekly farmer’s market, to our new Jefferson Accelerator Zone for innovation, our employees’ passion for the community is evident by the daily gestures towards our patients, students and each other.