The fellow will investigate how fluid flows and biophysical forces shape the developing heart using zebrafish models and human stem cells. The role involves studying the cilium's role as an antenna to translate extracellular signals into molecular processes.
Requirements summary
Candidates must hold a PhD, MD, or equivalent doctoral degree with a strong background in zebrafish research. Proficiency in advanced microscopy, gene editing, and molecular biology techniques is required.
Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. POSITION SUMMARY The laboratory of Dr. Shiaulou Yuan at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) is seeking highly motivated candidates for a full-time postdoctoral research fellow position. We are a multidisciplinary group of biologists, biophysicists, and microscopists who aim to understand how fluid flows and biophysical forces shape the developing heart and how these mechanisms underlie cardiac disease pathogenesis when gone awry. Specifically, we seek to illuminate how the cilium, a hair-like structure found on most cells in the human body, acts as an “antenna” to sense and translate extracellular signals into molecular processes that sculpt the early heart (Djenoune, Mahamdeh et al., Science, 2023). The penultimate goal of our research is to advance our understanding of cardiac development and diseases by combining state-of-the-art approaches from developmental biology, cell biology, genetics, biophysics, and advanced microscopy in zebrafish animal models and human stem cells. This position offers excellent opportunities to work in a highly collaborative and multi-disciplinary biomedical atmosphere, interact with distinguished scientists, physicians and physician-scientists at MGH-Harvard, and become a valued member of a collegial and growing research team. As a member of Harvard University, Massachusetts General Hospital, Mass General Brigham, and the Boston scientific community, the candidate will be immersed in a rich environment for zebrafish genetics, cardiovascular biology, cilia signaling, molecular biology, and imaging technologies.
Required
SKILLS
AND
Experience
The ideal candidate will have:
a strong background working with zebrafish
a PhD, MD, MD/PhD or equivalent doctoral degree in a relevant field
prior training in zebrafish husbandry and colony management, embryo micro-injection, embryo micro-dissection, confocal or light sheet microscopy, live cell imaging, quantitative image analysis, immunofluorescence, in situ hybridization, molecular cloning, CRISPR-Cas9 gene editing, recombinant protein, and/or human stem cell culture techniques
a passion for developmental biology, cell biology, cardiovascular biology, and microscopy
the ability to work independently and also as part of a team
excellent written and verbal communication skills
a strong work ethic and superb attention to details
exceptional technical and experimental skills.
experience training and supervising junior scientists, technicians and/or students Interested candidates should send a CV, a cover letter, and contact information for three references to Dr. Shiaulou Yuan (shiaulou.yuan@mgh.harvard.edu).
Find out more about our lab’s research: https://yuan.mgh.harvard.edu The expected annual salary range will be commensurate with the candidate’s experience and qualifications, and institutional guidelines. Review of applications will begin immediately and continue until the position is filled. EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. Job Summary Summary
Does this position require Patient Care? No
Essential Functions Qualifications Education Can this role accept experience in lieu of a degree? Licenses and Credentials Experience
Knowledge, Skills and Abilities
Additional Job Details (if applicable) Physical Requirements Standing N/A = (0%) Walking N/A = (0%) Sitting N/A = (0%) Lifting N/A = (0%) Carrying N/A = (0%) Pushing N/A = (0%) Pulling N/A = (0%) Climbing N/A = (0%) Balancing N/A = (0%) Stooping N/A = (0%) Kneeling N/A = (0%) Crouching N/A = (0%) Crawling N/A = (0%) Reaching N/A = (0%) Gross Manipulation (Handling) N/A = (0%) Fine Manipulation (Fingering) N/A = (0%) Feeling N/A = (0%) Foot Use N/A = (0%) Vision - Far N/A = (0%) Vision - Near N/A = (0%) Talking N/A = (0%) Hearing N/A = (0%) Remote Type Onsite Work Location 149 Thirteenth Street Building 149 Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.
