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Lead the scientific design and execution of early-phase clinical trials focusing on cardiometabolic diseases. Author core clinical documents and collaborate cross-functionally to interpret clinical, PK/PD, and biomarker data.
Requirements summary
Requires a PhD, MD, or PharmD with 3-7+ years of experience in clinical development or translational medicine. Strong expertise in cardiometabolic biology and early-phase clinical trial methodology is highly preferred.
Clinical Development Scientist/Senior Clinical Development Scientist
Tenvie Therapeutics is developing precision‑engineered small molecule therapies to address core drivers of neurological and peripheral diseases: neuroinflammation and cellular dysfunction.
Leveraging its proprietary product engine, Tenvie has the unique ability to advance both fully CNS‑penetrant and peripherally restricted products across a broad portfolio.
Tenvie’s most advanced programs, TNV262 and TNV108, are in Phase 1 clinical development.
TNV262 is a fully CNS-penetrant NLRP3 inhibitor targeting cardiometabolic and neuroinflammatory indications, including obesity and cardiovascular disease, and multiple sclerosis.
TNV108 is a peripherally restricted SARM1 allosteric inhibitor targeting peripheral neuropathies.
Tenvie’s clinical pipeline is complemented by discovery-stage programs across a range of related indications.
Tenvie Therapeutics is seeking a scientifically rigorous and highly collaborative Clinical Scientist to support the design and execution of early clinical development programs in cardiometabolic disease and related indications.
This role is ideal for candidates with a strong background in human pathophysiology and clinical trial design who are motivated to translate biology into impactful therapies.
The Clinical Scientist will work closely with Clinical Development, Clinical Operations, Biometrics, Translational Science, and Regulatory to ensure high‑quality clinical plans, protocols, and data readouts.
This role can be remote, hybrid, or on-site, and reports within the Clinical Development group.
Job responsibilities
Contribute to clinical strategy and study design
Support development of clinical development plans, target product profiles, and indication prioritization
Lead or co‑lead the scientific design of Phase 1–2 studies (e.g., FIH, dose‑finding, PoC) including objectives, endpoints, inclusion/exclusion criteria, and biomarker strategy, with emphasis on cardiometabolic risk factors and outcomes
Integrate nonclinical, translational, and clinical data to inform dose selection, schedule, and patient population
Lead development of core clinical documents
Author or co‑author clinical sections of protocols, protocol amendments, IBs, ICFs, CSRs, and relevant regulatory documents (e.g., briefing books, responses to health authority questions)
Develop and maintain study‑level documents including synopsis, statistical analysis‑relevant endpoint definitions, and data review plans
Partner with Biostatistics and Clinical Pharmacology on endpoint hierarchy, PK/PD modeling plans, and interim analyses
Drive study conduct and data quality
Serve as Clinical Scientist lead on cross‑functional study teams for selected trials
Provide clinical and scientific input into site selection, eligibility adjudication, and key study tools (e.g., manuals, training decks, CRFs)
Participate in ongoing medical and scientific data review (safety, PK/PD, biomarkers, efficacy signals); help define and track key data review listings and visualizations
Support development and execution of safety review / dose escalation committees and data monitoring activities
Lead data interpretation and communication
Lead or co‑lead integrated analyses of clinical, PK/PD, and biomarker data to generate clear conclusions and next‑step recommendations
Prepare data summaries and presentations for internal governance, external collaborators, and advisory boards
Contribute to abstracts, posters, and manuscripts for scientific meetings and peer‑reviewed journals
Interface with investigators and external partners
Provide scientific support to investigators and study sites (e.g., training, protocol clarification, scientific Q&A)
Participate in KOL and expert advisory boards, contributing to agenda, content, and follow‑up
Collaborate with CROs, central labs, imaging/biomarker vendors, and other partners to ensure alignment on scientific and operational expectations
Contribute to portfolio and organizational excellence
Support cross‑program learnings and standardization of endpoints, assessments, and data structures across cardiometabolic and related indications
Help refine internal processes and templates for protocols, charters, and data review
Mentor junior team members as appropriate; model a high‑accountability, low‑ego, cross‑functional working style
Qualifications
Education
PhD in life sciences, pharmacology, physiology, or related field strongly preferred; MD, PharmD, or equivalent clinical degree also considered
Strong foundation in cardiometabolic biology (e.g., obesity, insulin resistance, dyslipidemia, NAFLD/NASH, cardiovascular risk) is highly preferred
Experience
Typically 3–7+ years of relevant experience in clinical development, clinical pharmacology, or translational medicine within biotech/pharma or equivalent academic clinical research environment
Demonstrated experience contributing to design and execution of early‑phase (Phase 1–2) clinical trials
Cardiometabolic and/or obesity clinical trial experience preferred, including familiarity with standard endpoints (e.g., glycemic control, body weight, lipids, blood pressure, imaging or functional assessments)
Experience working on cross‑functional teams with Clinical Operations, Biometrics, Regulatory, and Translational/Discovery
Prior involvement in regulatory submissions (e.g., IND/CTA, briefing packages, responses to queries) is a plus
Technical skills
Strong understanding of clinical trial methodology, GCP, and the overall drug development pathway from FIH through proof‑of‑concept
Comfort interpreting PK/PD, biomarker, and clinical efficacy/safety data, and working with statisticians and pharmacometricians
Experience with cardiometabolic risk scoring, metabolic biomarker panels, or imaging modalities is an advantage
Excellent scientific writing skills with a track record of clear, structured documents and presentations
Core competencies
Highly organized, with the ability to manage multiple studies or workstreams in parallel in a fast‑paced environment
Strong analytical and critical‑thinking skills; able to move from complex data to clear, actionable recommendations
Effective communicator, able to tailor scientific messages to diverse audiences (clinicians, scientists, operations, leadership, regulators)
Demonstrated ability to work collaboratively and constructively across disciplines and with external partners
Comfortable operating with ambiguity and evolving data; proactive in identifying risks and proposing solutions
Commitment to high ethical standards, patient safety, and data integrity
Expected salary range
• $125,000-180,000 annual base salary
Tenvie is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit and business need.
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