The Senior Scientist will validate targets and assess the efficacy of therapeutic candidates for allergic and inflammatory diseases using in vitro and in vivo methods. Responsibilities include developing disease mouse models, executing cell-based assays, and communicating results to cross-functional teams.
Requirements summary
Requires a Ph.D. in Biology, Immunology, or a related field with extensive experience in multi-parameter flow cytometry and mouse model optimization. Preference is given to candidates with 5-8 years of relevant research experience and a strong record of high-quality scientific publications.
postgraduate degreeData AnalysisPanel DesignTarget ValidationSurgical TechniquesScientific WritingImmunologyCell-Based AssaysELISAFlow CytometryMSDHistologyMouse Model DevelopmentCytokine MeasurementPrimary Cell AssaysMulti-parameter Flow CytometryIn Vivo Efficacy
Job description
Regeneron is seeking a Senior Scientist to join a highly collaborative Immunology & Inflammation team.
This individual will have the opportunity to support a broad pipeline in allergic and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules in vitro and in vivo, and interrogating mechanisms of pathology that inform therapeutic strategies.
Candidate should have prior Immunology experience and prefer working in a team-driven environment, possess organizational skills and communicate openly and frequently with manager and team members.
As a Senior Scientist, a typical day may include: Contributes to project advancement by developing new methods and technologies.
Troubleshoots methodological and technical issues, interprets experimental data and literature, and communicates results to supervisor, department, or project team.
Executes experiments based on projects/protocols provided and works towards independently developing project.
Collaborates and communicates efficiently with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts.
Experience with proper handling and care of mice, general surgical techniques and the collection of blood and tissue samples.
Develops and optimizes relevant disease mouse models and the subsequent analysis of associated disease-related pathologies by flow cytometry, histology and ELISA.
Develops and executes cell-based assays to screen candidate antibodies for various research programs.
Performs ELISAs and or MSDs to measure cytokine levels and determine antigen binding for various research programs.
Contributes to lab and equipment maintenance and orders supplies/reagents to help create a safe, effective and efficient working environment.
This role may be for you if: You enjoy working in a fast-paced environment You are a fast learner and have desire to expand your skill set and learn new techniques You are detail oriented, well-organized and can multi-task You are a great teammate You have strong communication skills To be considered, you must have the following: Ph.D + 0-2+ years experience.
The ideal candidate will be skilled in the design of complex studies to interrogate the in vivo efficacy of novel therapeutics and thus, will have experience with developing and optimizing mouse models of inflammatory diseases and analysis of associated disease-related pathologies by flow cytometry, histology and ELISA.
Benefits
Dental Insurance
Disability Insurance
Life Insurance
Paid Time Off
Health Insurance
Vision Insurance
Parental Leave
Military Leave
Annual Bonuses
Equity Awards
Family Support Benefits
Fitness Centers
401(k) Company Match
Qualified applicants will preferably have minimum of 5-8 years of relevant research experience in immunology.
Ph.D. in Biology, Immunology, or Cellular and Molecular Biology preferred but not required.
Extensive experience with multi-parameter flow cytometry, panel design and data analysis is required.
Basic computer literacy and experience collecting and analyzing biological data on the computer is a necessity.
Preferred experience with the following data analysis programs: GraphPad PRISM, Softmax Pro, FlowJo analysis, HALO, DIVA software.
Knowledge of allergic and inflammatory diseases, with emphasis in skin and/or lung biology is preferred.
Preferred experience developing and optimizing primary cell assays used to characterize cytokine and immunoreceptor pathways and screen antibody candidates.
Must have a record of high-quality publications in scientific literature.
The candidate is expected to have effective verbal communication and written skills.
Does this sound like you?
Apply now to take your first step towards living the Regeneron Way!
We are committed to building a workplace with an inclusive culture.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.
Where necessary, we disclose salary ranges for roles in all countries in which we operate.
The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience.
In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.
Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.
If you have any questions, please speak with your recruiter.
Please be advised that at Regeneron, we believe we do our best work when we are together.
For that reason, many roles are required to be performed on‑site.
Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.
As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based.
The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.
For jobs in Canada: this posting is for an existing position.
Salary Range (annually) $109,900.00 - $179,300.00 Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases.
Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories.
Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases.
Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.
