Job detail

Postdoctoral Fellow - Cancer Research and RNA-Based Therapeutics

City of Hope

#Structural Biology #Computational Biology #Drug Discovery #Cell Biology #Cancer Research #Molecular Biology #Systems Biology #Epigenetics

Quick overview

The fellow will conduct research on genetic and epigenetic regulations in tumorigenesis, focusing on RNA epigenetics and RNA-based therapeutics. Key tasks include developing mRNA-based vaccines and CAR-T/NK/Macrophage technologies using advanced molecular and cellular techniques.

Requirements summary

Candidates must hold a Ph.D. and/or M.D. with a strong background in RNA biology, epitranscriptomics, or immunology. Experience with mouse model research is preferred.

postgraduate degreeDrug DevelopmentImmunologyMass SpectrometryBiochemistryFlow CytometryChemical BiologyMouse GeneticsChIP-seqRNA BiologySingle-cell SequencingRNA-seq AnalysisLNP DevelopmentSpatial SequencingmRNA-based TherapeuticsXenograft AssaysMetabolism Profiling

Job description

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses.
Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
The laboratory of Dr.
Jianjun Chen is in search of a talented Postdoctoral Fellow.
Our group is interested in discovering novel genetic and epigenetic regulations and deciphering their underlying molecular mechanisms in normal developmental processes and tumorigenesis.
Our research spans multiple areas, including RNA Biology, Cancer Biology, Chromatin and Epigenetic Regulation, Cancer Metabolism, Immunology, Drug Discovery and Development, and Structural Biology, with a particular emphasis on RNA epigenetics/epitranscriptomics (RNA modifications) and RNA-based therapeutics.
A major focus of our translational efforts is the development of mRNA-based therapeutics, particularly in vivo CAR-T/NK/Macrophage technologies and cancer mRNA vaccines, as well as epitranscriptomics-based biomarkers for cancer diagnosis, prognosis, and therapeutic response prediction.
Our research involves experiments with RNA Biology, RNA modifications/editing, mRNA-based therapeutics, lipid nanoparticle (LNP) and alternative delivery systems, targeted delivery, cancer immunology, auto immune disease, primary human cancer cells, cancer and stem cell transplantation models, mouse genetics, molecular biology, biochemistry and cell biology, chemical biology, immunology, functional genomics, CARIPSR screening, signal transduction, single-cell sequencing, spatial sequencing, metabolism, drug development, structural biology, and large-scale data analysis and computational biology.
For more information about Dr.
Chen’s lab, please visit here.
As a successful candidate, you will: Engage in a variety of advanced techniques, including but not limited to mRNA-based technologies, LNP development, targeted delivery, Flow cytometry, mass spectrometry/quantitative phospho-profiling, CyTOF, mouse genetics models, xenograft assays, retroviral gene delivery, chemical biology, drug development, whole exome sequencing and RNA-seq-analysis of clonal evolution of cancer, dot blots, RNA modification-seq, ChIP-seq, RIP-seq, PAR-CLIP-seq, single-cell sequencing, spatial sequencing, metabolism profiling, and pre-clinical drug testing in xenotransplantation models, etc.

Postdoctoral Fellow - Cancer Research and RNA-Based Therapeutics

Quick overview

Requirements summary

Job description

Your qualifications should include

Preferred Qualifications

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