The fellow will design and conduct in vivo efficacy studies to test gene editing and small-molecule splicing modulators in mouse models of Familial Dysautonomia. Responsibilities include performing downstream molecular analyses, optimizing therapeutic delivery, and contributing to scientific manuscripts and grants.
Requirements summary
A Doctoral degree (preferably Ph.D.) in neuroscience, molecular biology, genetics, or a related field is required. Candidates should have strong experience in molecular biology techniques, rodent models, and a track record of peer-reviewed publications.
Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary
Please send you
CV/Resume,
Cover
Letter and
References directly to: Dr. Elisabetta Morini EMORINI@mgh.harvard.edu for this position. A linked application is not available. The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD), a rare neurodegenerative disease. This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular, cellular, and genomic approaches to assess therapeutic outcomes. We are seeking a creative, independent, and collaborative scientist with a strong background in molecular neuroscience, gene editing, RNA biology, or neurogenetics. Experience working with mouse models, including behavioral assays and molecular analysis of tissues, is highly desirable. This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem, providing access to state-of-the-art resources and a vibrant scientific community.
Duties and Responsibilities
Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
Perform downstream analyses, including RNA/protein quantification, splicing analysis, and histological assessments.
Lead the development and optimization of therapeutic delivery and molecular assays.
Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
Prepare manuscripts, present findings at scientific meetings, and contribute to grant applications. The ideal candidate should have received (or expect to receive soon) a Doctoral degree, preferred Ph.D. in neuroscience, cell or molecular biology, human genetics, biochemistry, or related field. Qualifications EDUCATION: Minimum Required: Doctoral Degree EXPERIENCE: Required: Doctoral degree Preferred: Ph.D. in neuroscience, molecular biology, genetics, or a related field. Desired skills and competencies:
Molecular biology techniques including DNA, RNA, and protein isolation and manipulation (RT-PCR, qRT-PCR, western blotting)
Good understanding of genetic methodologies, with experience in cloning, CRISPR/Cas genetic editing techniques, genomic sequencing
Some level of cell culture experience, including cell lines generation, transfection/transduction, selection, propagation, preservation, and phenotypic characterization
Prior experience with rodent models, gene editing, or RNA splicing is strongly preferred.
Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques
Histological and immune-histochemical techniques.
First (or co-first) author of one or more peer-reviewed scientific publications
Excellent English verbal and written communication skills
Able to work both independently and in a team Interested applicants should submit their CV/Resume, Cover Letter and References to: Dr. Elisabetta Morini EMORINI@mgh.harvard.edu Please do not apply through this link. Additional Job Details (if applicable) Remote Type Hybrid Work Location 185 Cambridge Street EEO Statement: 1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.
