Medical University of South Carolina
Location
Charleston, South Carolina
Salary
$52,100 - $88,600 / YEAR
The candidate will manage the logistical organization of a basic science laboratory, focusing on murine model breeding and leukemia research. They will also perform high-throughput immunologic experiments on human patient samples and analyze the resulting data.
A bachelor's degree in a natural or health science and two years of clinical or research experience are required. A master's degree in biology or immunology with three years of experience is preferred.
Summary The Paczesny Laboratory in the Hollings Cancer Center and the Department of Pharmacology and Immunology at the Medical University of South Carolina has an open position for a Research Specialist III. Our laboratory integrates in vivo murine models and human clinical samples to elucidate mechanisms of immunity and tolerance in myeloid malignancies and hematopoietic cell transplantation (HCT). A central aspect of this position is hands-on work with both animal models and human biospecimens, and candidates must be comfortable and experienced in working in both settings. Entity Medical University of South Carolina (MUSC - Univ) Worker Type Employee Worker Sub-Type Research Grant Cost Center CC001034 COM PHARM Operations CC Pay Rate Type Salary Pay Grade University-GEN09 Pay Range 52,100.00 - 70,300.00 - 88,600.000 Scheduled Weekly Hours 40 Work Shift
The selected candidate will be responsible for the maintenance and logistical organization of a basic science laboratory, with particular emphasis on helping the post-docs and staff scientist with breeding of animals and their murine models of leukemia and HCT. In addition, the candidate will help the PI performing ELISA on thousands of patients’ samples, and flow cytometry as well as analyze these data. We seek a highly motivated individual with previous experience these technologies. Candidate should send CV and a list of three references directly to Dr. Sophie Paczesny by email (paczesns@musc.edu). Key Responsibilities/ Percent Effort The selected candidate will play a critical role in supporting the laboratory’s research mission and daily operations. Responsibilities and specific tasks will be as follows: Perform routine handling of mice including monitoring, treatments, and experimental procedures) (20%). Assist with breeding, colony management, and genotyping of transgenic. Maintain accurate animal records and ensure compliance with institutional animal care and biosafety protocols. Assist with intravenous and intraperitoneal injections of novel therapeutics (cellular of antibody-based). Perform immunologic experiments on murine models (e.g., harvest organ, digest, flow cytometry, confocal, etc) (20%). Immunology experimentation employing various techniques, including isolation and purification of T cells, and regulatory T cells. Sort T cells and other hematopoietic or immunes cells. Perform isolation of cells, cell culture and in vitro functional assays (10%). Harvest murine organs, including spleen, liver, bone marrow, and lungs. Perform tissue digestion and preparation of single-cell suspensions. Perform isolation and purification of T cells, and regulatory T cells. Sort T cells and other hematopoietic or immunes cells. Maintain cell lines; viability, cytotoxicity assay; transfection and infection, etc. Prepare patients samples per lab good practice and perform immunologic experiments (e.g., high-throuput ELISA, flow cytometry, etc) (15%). These responsibilities include receiving or shipping samples, organizing them, and storing them in freezer following lab established freezer maps. Thaw precious plasma or PBMCs patients’ samples following rigorous protocols and perform sequential ELISA or flow cytometry and analysis. Assist with daily lab operations including routine maintenance of and experimentation in mice (15%). The selected candidate will assist with daily lab operations including stocking consumable items and reagents, making buffers, and aliquoting reagents. Fill liquid nitrogen to keep frozen cells alive. Autoclave the biologic trash and prepare and maintain lab work (e.g., fill and autoclave tips, clean hood and incubator). Facilitate general maintenance of the research space by working with MUSC to ensure that the laboratory area is maintained and that repairs, waste disposal, and cleaning needs are addressed in a timely manner. Records and analyzes results of research experiments (15%) Collect research experimental data and analyze results and generate figures. Additional duties assigned by the Principal Investigator (5%). This will include helping refine or prepare lab protocols, maintain IBC and IACUC protocols up to date. Train new lab members for basic experiments. MUSC Minimum Training and Experience Requirements: A bachelor's degree in chemistry, biology, or other natural, life or health care science directly related to the assigned area of research and two years advanced journel-level work experience in a clinical or research setting. Must have previous experience in a laboratory. Preferred
Ideally a master’s in biology or immunology with at least 3 years of experience in this field. Strong organizational, record keeping, interpersonal and communication skills required. Must be able to perform complex calculations, to follow complicated experimental procedures and methods and develop independence with tasks and experiments. Prior experience working with patients’ samples handling as well as mice handling, and flow cytometry is valued. Some weekend, holidays and/or evenings may be required. Must be organized and have attention to details. All personnel are expected to maintain laboratory notebooks and store all the data in the lab shared drive. Additional
Minimum Requirements: A bachelor's degree in chemistry, biology, or other natural, life or health care science directly related to the assigned area of research and two years advanced journel-level work experience in a clinical or research setting. Physical Requirements: (Note: The following descriptions are applicable to this
Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32° F to 100° F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/40 vision, corrected, in one eye or with both eyes. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous) Additional New Requirements: Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required. If you like working with energetic enthusiastic individuals, you will enjoy your career with us! The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need. Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees Thank you for wanting to be part of the Medical University of South Carolina team. Whether you want to teach the next generation of health care leaders, innovate new business models, discover the next breakthrough or provide patient care, there's a role for you that fuels your passion and takes advantage of your skills. There are career opportunities available in academics, research, hospital medicine, physician practices and support services, from patient billing to IT. As an applicant, you can search jobs for all MUSC entities as well as search by category and location. MUSC attracts more than $250 million annually in research funding, making it the biggest magnet for biomedical, extramural research dollars of all institutions of higher learning in South Carolina. The Clinical and Translational Science Award (CTSA) Program aims to advance clinical and translational science to increase the speed at which new treatments become available to patients. MUSC Health, the clinical enterprise, operates a 750 bed medical center, which includes a nationally recognized Children’s Hospital, the Ashley River Tower (cardiovascular, digestive disease, and surgical oncology), Hollings Cancer Center (one of fewer than 70 elite National Cancer Institute designated centers), a Level I Trauma Center and the Institute of Psychiatry. In addition, there are more than 100 outreach clinics, hospital/health system affiliations, and telehealth sites. U.S. News & World Report placed us among the top one percent of all American hospitals, with 11 specialties in the top 50. The MUSC Medical Center is also one of only three Magnet® designated hospitals in South Carolina.
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